RESEARCH
Overview
Dr. Kuhn’s research integrates neuroimaging, neuropsychological assessment and neuromodulation to investigate functional neuroanatomy - that is, what brain networks and brain functions give rise to each aspect of cognition, emotion, and behavior. This is also called the brain-behavior relationship. Neuroimaging allows the brain’s structure, activity, and connectivity to be viewed, directly measured and quantified. Neuropsychological assessment allows for cognition (e.g. attention, memory, problem solving), emotion (e.g. anxiety, depression), and behavior (e.g. motor skills, real world function) to be quantified. Brain and neuropsychological changes caused by healthy development, healthy aging, neurologic and psychiatric diseases are used to test theories about the brain-behavior relationship. Neuromodulation, such as with focused ultrasound or transcranial magnetic or electrical stimulation, also allows for specific regions of the brain to be changed. Then, neuroimaging and neuropsychological assessment can assess how those changes affect the structure and function of the brain, cognition, emotion and behavior. In this way, Dr. Kuhn’s research seeks to further our understanding of the brain-behavior relationships and help develop and validate clinical tools for improving cognition and emotion across a host of neurological and psychiatric conditions.
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Connectivity-based parcellation of the amygdala and identification of its main white matter connections.
Avecillas-Chasin, J. M., Levinson, S., Kuhn, T., Omidbeigi, M., Langevin, J. P., Pouratian, N., & Bari, A. (2023). Scientific reports, 13(1), 1305.
The Role of the Insula in Classical and Dissociative PTSD: A Double Case Study
Blades, R., Becerra, S., Jordan, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2022). Neurocase, 1-9.
A Systematic Approach to Neuropsychiatric Intervention: Functional Neuroanatomy Underlying Symptom Domains as Targets for Treatment
Kuhn, T., Haroon, J., & Spivak, N. M. (2022). Focus, 20(1), 45-54.
Ultrasound as a Neurotherapeutic: A Circuit-and System-Based Interrogation
Spivak, N. M., Tyler, W. J., Bari, A. A., & Kuhn, T. P. (2022). Focus, 20(1), 32-35.
A Pilot Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder
Mahdavi, K., Jordan, S., Habelhah, B., Zielinski, M., Haroon, J., Becerra, S., ... & Kuhn, T. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1627.
A Case Study of Low-intensity Focused Ultrasound for Treatment-Resistant Generalized Anxiety Disorder and Major Depressive Disorder
Zielinski, M., Mahdavi, K., Jordan, S., Haroon, J., Habelhah, B., Beccera, S., ... & Kuhn, T. Bystrisky, A. (2021). Brain Stimulation: Basic, Translational, and Clinical Research in Neuromodulation, 14(6), 1667.
Treating Dissociative Post-Traumatic Stress Disorder Presenting as a Functional Movement Disorder with Transcranial Magnetic Stimulation targeting the Cingulate Gyrus
Blades, R., Jordan, S., Becerra, S., Eusebio, B., Heatwole, M., Iovine, J., ... & Kuhn, T. (2020). Neurological Sciences, 41(8), 2275-2280.
Episodic and Semantic Memory Disorders
Bauer R.M., Gaynor L., Moreno C., Kuhn T. (2019). In: Ravdin L., Katzen H. (eds) Handbook on the Neuropsychology of Aging and Dementia. Clinical Handbooks in Neuropsychology.
Effects of fMRI navigated TMS on treatment outcomes in major depressive disorder
Packham, H.R. & Nicodemus, N.E. & Jordan, S.E. & Whitney, M. & Pereles, F.S. & Duncan, J.C. & Becerra, S.B. & Bystritsky, A. & Kuhn, Taylor & Mamoun, Michael. (2018). Brain Stimulation.
Episodic and Semantic Memory Disorders
Kuhn, T., Bauer, R.M. Clinical Handbook of Neuropsychology (2013). Springer Science & Business Media, New York, USA.